Endocrine Abstracts

Introduction: Cross sex hormonal therapy with testosterone is used in female-to-male transgender people to induce the desired secondary sexual features; this could lead to an increased risk of cardiovascular diseases. Data published on this subject is scarce and contradictory.Objective: To evaluate effects on weight, inflammatory and prothrombotic parameters, lipid profile, and insulin resistance after 3–4 months of testosterone treatment in transse...

Introduction: Thyroid cancer is the most frequent malignant endocrine neoplasia. Its incidence has significantly risen worldwide in the last decades.Objective: To estimate the incidence of thyroid cancer in Valladolid’s east area population, Spain, over the period 2002–2016.Methods: A retrospective descriptive research was performed in the Clinical Universitary Hospital of Valladolid (HCUVa). Clinical data was obtained fr...

ContextThe effects of COVID-19 on the thyroid axis remain uncertain. Recent evidence has been conflicting, with Euthyroid-Sick-Syndrome-ESS, thyrotoxicosis or suppression of thyroid-function-tests (TFTs) reported which can lead to inadequate diagnoses and treatments.ObjectiveThe aim of this case report is to describe, for the first time, a possible interference of macro-TSH in a patient with SARS-CoV2 and thy...

ContextThe incidence of Type 2 diabetes mellitus (T2DM) is increasing and muscle strength and function are reported to be decreased in patients with T2DM compared to healthy controls.However, the relation between bone and muscle remain unclear.ObjectiveOur aims was to examine bone health parameters [by Dual energy X-ray absorptiometry (DXA) and trabecular bone score (TBS)] and muscle strength (by hand grip) i...

Puberty is a key maturational process that culminates with the acquisition of reproductive capacity. This event demands significant energy resources to support the profound biological changes that occur during this period, including the activation of the reproductive axis. To this end, a plethora of signals operate for transmitting metabolic information to the reproductive axis in order to precisely regulate pubertal awakening depending on energy availability. Among others, gh...

Introduction: The prevalence of hepatic steatosis in people with obesity is very high. However, what is relevant is to detect those patients with associated fibrosis. The aim of the present study was to predict by artificial intelligence (AI) using clinical-analytical parameters, the presence of liver fibrosis in the biopsy performed during bariatric surgery (BS) of patients with obesity.Subjects and methodology: Cross-sectional study of patients with ob...

Objective: Growth hormone (GH) is used for metabolic indications in the treatment of adult patients with GH deficiency (GHD). In addition to influencing growth processes in childhood, GH is important in regulating metabolic processes at every stage of life. GH, via insulin-like growth factor (IGF-1), has an anabolic effect on protein metabolism, also in skeletal muscles and cardiac muscle. Moreover, myokines produced by muscle fibers stimulated by muscle contraction, acting in...

Aim: Illustrating a case series of two patients with levothyroxine malabsorption and suboptimal control of the thyroid profile who experienced a significant improvement after switching to liquid levothyroxine.Material and Methods: Case saries of two patients who were attended in monographic thyroid pathology consultations at Virgen Macarena University Hospital.Results: Case 1: a 46-year-old female patient who had multinodular goitr...

Introduction: Paragangliomas and pheochromocytomas (PGGs) are infrequent tumors of the autonomic nervous system that represent a diagnostic and therapeutic challenge. Management and follow-up of PGGs requires specialized knowledge and solid experience, which, given the rarity of these diseases, is available only in highly specialized centers. University Hospital La Fe (Spain) was designated a reference unit on Neuroendocrine Tumors by local sanitary authorities in 2018. The ai...

RationaleLiver cirrhosis frequently leads to changes in body composition consisting of a loss of lean mass, increased body water and variable alterations of fat mass. Changes in body composition may occur after liver transplantation (LT). Our aim was to study the changes that occur in body composition after LT (in the postoperative period after LT as well as 1 month later). Methods: A body composition study was carried out using th...